Taking Alpha-Lipoic Acid for 40 days after Carpal Tunnel Surgery can decrease the likelihood of developing Pillar Pain.

Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.

The Skinny – A double-blind, randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA), while the other 32 received the placebo pill. 

alpha lipoic acid carpal tunnel

In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, presence or absence of pillar pain, use of analgesics beyond post-op day 2, and sensory and motor conduction velocities.   These measures were assessed at three months post-op. 

Bringing it Home –  ALA did not significantly improve nerve conduction velocity or Boston Carpal Tunnel score. Taking ALA did reduce pillar pain, and static 2-point discrimination improved in both groups. 

Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain.   The study size was relatively small, and the outcome measures of pain and two-point discrimination test are somewhat subjective measures. The ALA treatment (pillar pain treatment) was well tolerated by the study participants. A larger study is needed to confirm these findings. 

Leave a Comment






More To Read

The function of the Glenohumeral Joint Ligaments

January 30, 2022

Glenohumeral Joint  Ligaments  The Glenohumeral (GH) joint is composed of the head of the humerus and the glenoid fossa. The fossa is relatively small compared to the humeral head, making the joint highly mobile, which also leads to an increased risk of instability.     The glenoid labrum is a fibrocartilagenous rim attached around the…

Cervical Spinal Cord Injuries Impact on Hand Function

April 7, 2026

By: Hannah Schleining Cervical Spinal Cord Injuries Impact on Hand Function The cervical region controls many of the muscles responsible for upper extremity movement,therefore, injuries at this level can dramatically influence strength, coordination, andindependence in everyday function. Understanding how cervical spinal cord injuries affect upperextremity function is essential for clinicians, caregivers, and individuals navigating recovery.…

Test for Distal Radial Ulnar Joint of the Wrist

April 3, 2024

Ballottment Test for Wrist DRUJ Reliability and Validity Analysis of the Distal Radioulnar Joint Ballottement Test Nagashima, M., Omokawa, S., Hasegawa, H., Nakanishi, Y., Kawamura, K., & Tanaka, Y. (2024). Reliability and validity analysis of the distal radioulnar joint ballottement test. The Journal of Hand Surgery, 49(1), 15–22. https://doi.org/10.1016/j.jhsa.2023.10.006 The Skinny: Distal radioulnar joint (DRUJ)…

Radial Nerve Palsy: A Paralysis Causing Wrist Drop

August 24, 2024

Radial Nerve Palsy- Treatment

Envelope_1

Sign-up to Get Updates Straight to Your Inbox!

Sign up with us and we will send you regular blog posts on everything hand therapy, notices every time we upload new videos and tutorials, along with handout, protocols, and other useful information.