Taking Alpha-Lipoic Acid for 40 days after Carpal Tunnel Surgery can decrease the likelihood of developing Pillar Pain.
Filed under Reviews, Treatments
Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.
The Skinny – A double-blind, randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA), while the other 32 received the placebo pill.

In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, presence or absence of pillar pain, use of analgesics beyond post-op day 2, and sensory and motor conduction velocities. These measures were assessed at three months post-op.
Bringing it Home – ALA did not significantly improve nerve conduction velocity or Boston Carpal Tunnel score. Taking ALA did reduce pillar pain, and static 2-point discrimination improved in both groups.

Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain. The study size was relatively small, and the outcome measures of pain and two-point discrimination test are somewhat subjective measures. The ALA treatment (pillar pain treatment) was well tolerated by the study participants. A larger study is needed to confirm these findings.
More To Read
Arthrodesis vs Arthroplasty in Thumb CMC OA
Piacenza A, Vittonetto D, Rossello MI, Testa M. Arthrodesis Versus Arthroplasty in Thumb Carpometacarpal Osteoarthritis: Impact on Maximal Voluntary Force, Endurance, and Accuracy of Pinch. J Hand Surg Am. 2021 May 24:S0363-5023(21)00199-4. doi: 10.1016/j.jhsa.2021.03.023. Epub ahead of print. PMID: 34045112. The Skinny: This was a retrospective study based on a convenience sample of individuals who…
The 4 Stages of Simple Wound Care in Hand Therapy
Wound care is messy. It can be intimidating and scary. With so many variations of wounds (for example, white skin around wound) and so many products out there it is hard to know what to use, when to use it, and how to use it. If you go to a wound care conference, you’ll spend most…
Peripheral nerve injury: A hand therapist’s assessment of sensory return.
Sensory return after a hand injury specifically a peripheral nerve injury After a peripheral nerve injury, there are often times impairments in sensory function and/or motor function. The rate of recovery varies based on the degree of injury, the overall health of the patient, and the patient’s age. After an injury, it is important…
Carpal Fractures: A Brief Overview
Carpal fractures account for 8% of fractures in the upper extremity. The carpals are situated between the (distal radius and ulna) and the metacarpals. They make up the proximal row- Scaphoid, Lunate, Triquetrum, and Pisiform, the distal row- Trapezium, Trapezoid, Capitate, and Hamate. Here are some of the most common carpal bone fracture Scaphoid…
Sign-up to Get Updates Straight to Your Inbox!
Sign up with us and we will send you regular blog posts on everything hand therapy, notices every time we upload new videos and tutorials, along with handout, protocols, and other useful information.