Taking Alpha-Lipoic Acid for 40 days after Carpal Tunnel Surgery can decrease the likelihood of developing Pillar Pain.
Filed under Reviews, Treatments
Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.
The Skinny – A double-blind, randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA), while the other 32 received the placebo pill.

In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, presence or absence of pillar pain, use of analgesics beyond post-op day 2, and sensory and motor conduction velocities. These measures were assessed at three months post-op.
Bringing it Home – ALA did not significantly improve nerve conduction velocity or Boston Carpal Tunnel score. Taking ALA did reduce pillar pain, and static 2-point discrimination improved in both groups.

Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain. The study size was relatively small, and the outcome measures of pain and two-point discrimination test are somewhat subjective measures. The ALA treatment (pillar pain treatment) was well tolerated by the study participants. A larger study is needed to confirm these findings.
More To Read
Top 5 Hand Therapy Toys for Kids
Many therapists in hand therapy clinics have a lot of tools for their adult patients, but may not have as many tools for the less common pediatric patient. With nearly 20 years experience in pediatrics, we’ve compiled a list of our top 5 picks for tools to use with pediatric patients in hand therapy. We…
Arthrodesis vs Arthroplasty in Thumb CMC OA
Piacenza A, Vittonetto D, Rossello MI, Testa M. Arthrodesis Versus Arthroplasty in Thumb Carpometacarpal Osteoarthritis: Impact on Maximal Voluntary Force, Endurance, and Accuracy of Pinch. J Hand Surg Am. 2021 May 24:S0363-5023(21)00199-4. doi: 10.1016/j.jhsa.2021.03.023. Epub ahead of print. PMID: 34045112. The Skinny: This was a retrospective study based on a convenience sample of individuals who…
Neurolutions IpsiHand to Aide in Stroke Rehabilitation in Patients with Hemiparesis
Neurolutions IpsiHand to Aide in Stroke Rehabilitation in Patients with Hemiparesis Hemiparesis occurs in approximately 77% of new stroke cases and often persists into thechronic stage (Humphries et al., 2021). Recent innovation, such as brain-computer interfaces(BCIs), offer new opportunities for motor recovery even years after stroke. One such approach is the Neurolutions IpsiHand System, an…
Exertional (Chronic) Compartment Syndrome of The Hand
By: Tommi Long What is it? Chronic exertional compartment syndrome (CECS) is an exercise-induced condition affecting the muscles and nerves, leading to pain, swelling, and reduced muscle function due to increased pressure and restricted circulation. While most commonly, it impacts the arms and legs, it is rare to happen in the hand(s). CECS is most…
Sign-up to Get Updates Straight to Your Inbox!
Sign up with us and we will send you regular blog posts on everything hand therapy, notices every time we upload new videos and tutorials, along with handout, protocols, and other useful information.