Taking Alpha-Lipoic Acid for 40 days after Carpal Tunnel Surgery can decrease the likelihood of developing Pillar Pain.
Filed under Reviews, Treatments
Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.
The Skinny – A double-blind, randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA), while the other 32 received the placebo pill.

In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, presence or absence of pillar pain, use of analgesics beyond post-op day 2, and sensory and motor conduction velocities. These measures were assessed at three months post-op.
Bringing it Home – ALA did not significantly improve nerve conduction velocity or Boston Carpal Tunnel score. Taking ALA did reduce pillar pain, and static 2-point discrimination improved in both groups.

Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain. The study size was relatively small, and the outcome measures of pain and two-point discrimination test are somewhat subjective measures. The ALA treatment (pillar pain treatment) was well tolerated by the study participants. A larger study is needed to confirm these findings.
More To Read
Outcomes of Rigid Night Splinting and Activity Modification in the Treatment of Cubital Tunnel Syndrome
Shah, C. M., Calfee, R. P., Gelberman, R. H., & Goldfarb, C. A. (2013). Outcomes of rigid night splinting and activity modification in the treatment of cubital tunnel syndrome (night splint for cubital tunnel syndrome). The Journal of Hand Surgery, 38(6), 1125–1130.e1. https://doi.org/10.1016/j.jhsa.2013.02.039 By: Sophia Grimm The Skinny: The purpose of this study was to…
EDS 101: Understanding Hypermobility in the Hand Therapy Setting
EDS in the Hand Therapy Setting General Overview:Ehlers Danlos Syndrome (EDS) is a group of heritable connective tissue disorders caused bygenetic changes that affect collagen production, the protein responsible for strength and elasticityin skin, ligaments and tendons (The Ehlers Danlos Society, 2016). There are thirteen forms of EDS that each have their own set of…
Carpal tunnel syndrome and its association with body mass index, wrist ratio, wrist to palm ratio, and shape index
A literature review of carpal tunnel syndrome and its association with body mass index, wrist ratio, wrist to palm ratio, and shape index Madani, A. M., Gari, B. S., Zahrani, E. M. A., Al-Jamea, L. H., & Woodman, A. (2022). A literature review of carpal tunnel syndrome and its association with body mass index, wrist…
Putting Occupation in Hand Therapy
It was early in my career, maybe a year out of school. I was working with a veteran physical therapist that had been practicing for thirty plus years. She was somewhat intimidating and one of those old school physical therapists that thrived on being aggressive. We were chatting about what areas of occupational hand therapy…
Sign-up to Get Updates Straight to Your Inbox!
Sign up with us and we will send you regular blog posts on everything hand therapy, notices every time we upload new videos and tutorials, along with handout, protocols, and other useful information.