Does Taking an Alpha-lipoic for 40 days after Carpal Tunnel Release decrease the likelihood of developing Pillar Pain?

Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.

The Skinny – A double-blind, randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA), while the other 32 received the placebo pill. 

pillar pain

In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, presence or absence of pillar pain, use of analgesics beyond post-op day 2, and sensory and motor conduction velocities.   These measures were assessed at three months post-op. 

Bringing it Home –  ALA did not significantly improve nerve conduction velocity or Boston Carpal Tunnel score. Taking ALA did reduce pillar pain, and static 2-point discrimination improved in both groups. 

Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain.   The study size was relatively small, and the outcome measures of pain and two-point discrimination test are somewhat subjective measures. The ALA treatment (pillar pain treatment) was well tolerated by the study participants. A larger study is needed to confirm these findings. 

Leave a Comment






More To Read

A Better De Quervain’s Tenosynovitis Test

November 10, 2019

J. F. Goubau, L. Goubau, A. Van Tongel, P. Van Hoonacker, D. Kerckhove, B. Berghs (2013).The wrist hyperflexion and abduction of the thumb (WHAT) test: a more specific and sensitive test to diagnose de Quervain tenosynovitis than the Eichhoff’s Test. J Hand Surg Eur Vol. 2014 Mar; 39(3): 286–292. Published online 2013 Jan 22. doi:…

Read More

The function of the Glenohumeral Joint Ligaments

January 30, 2022

Glenohumeral Joint  Ligaments  The Glenohumeral (GH) joint is composed of the head of the humerus and the glenoid fossa. The fossa is relatively small compared to the humeral head, making the joint highly mobile, which also leads to an increased risk of instability.     The glenoid labrum is a fibrocartilagenous rim attached around the…

Read More

Graded Motor Imagery in Hand Therapy

January 5, 2020

The 3 Stages of Graded Motor Imagery  We’ve all heard of mirror box therapy, but do you know the details of how it works? There’s actually 3 stages involved that exercise the brain and take advantage of its plasticity.  There is a great deal of evidence supporting these three stages and you can use them…

Read More

Orthotic Options for Hand Burns

January 17, 2021

By: Sophia Grimm Hand burns can be very challenging to treat, and successful rehabilitation begins early after acute injury. Following a burn injury, scar contractures are the primary reason for the deformity of the hand. Therefore, proper orthotic intervention is key to preventing joint and ligament contractures (Kelly, Berenz & Williams, 2019). Splinting goals following…

Read More
Envelope_1

Sign-up to Get Updates Straight to Your Inbox!

Sign up with us and we will send you regular blog posts on everything hand therapy, notices every time we upload new videos and tutorials, along with handout, protocols, and other useful information.