Does Taking an Alpha-lipoic for 40 days after Carpal Tunnel Release decrease the likelihood of developing Pillar Pain?
Filed under Uncategorized
Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.
The Skinny – A double-blind, randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA), while the other 32 received the placebo pill.
In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, presence or absence of pillar pain, use of analgesics beyond post-op day 2, and sensory and motor conduction velocities. These measures were assessed at three months post-op.
Bringing it Home – ALA did not significantly improve nerve conduction velocity or Boston Carpal Tunnel score. Taking ALA did reduce pillar pain, and static 2-point discrimination improved in both groups.
Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain. The study size was relatively small, and the outcome measures of pain and two-point discrimination test are somewhat subjective measures. The ALA treatment (pillar pain treatment) was well tolerated by the study participants. A larger study is needed to confirm these findings.
More To Read
Stretching Alone Can Change P1 Bone Shape in Patients with Camptodactyly
Woo Hong, S. Kim, J., Sang Kwon, O., Ho Lee, M., Sik Gong, H., Hyun Baek, G., (2019). Radiographic Remodeling of the Proximal Phalangeal Head Using a Stretching Exercise in Patients With Camptodactyly. J Hand Surg Am, 1.e1-1.e10 The Skinny – Camptodactyly is a congenital, nontraumatic flexion contracture of the PIP in fingers other than…
Carpal Tunnel Treatment: Splinting Only vs Splinting & Conservative Treatment
Short-term clinical outcome of orthosis alone vs combination of orthosis, nerve, and tendon gliding exercises and ultrasound therapy for treatment of carpal tunnel syndrome. Sim, Sze En et al. Journal of Hand Therapy, Volume 32, Issue 4, 411 – 416 The Skinny- Carpal tunnel syndrome (CTS) is the most common compression neuropathy. Compression of the…
Peripheral nerve injury: A hand therapist’s assessment of sensory return.
Sensory return after a hand injury specifically a peripheral nerve injury After a peripheral nerve injury, there are often times impairments in sensory function and/or motor function. The rate of recovery varies based on the degree of injury, the overall health of the patient, and the patient’s age. After an injury, it is important…
Should we still be immobilizing the thumb in scaphoid fractures, or is a wrist-only cast just as effective?
Article:Harper, K. J., Rees, Y., Tan, N. X., Li, H., Fonseca, E. A., Quach, P. G., Lee, G. S., Brayshaw, J.R., & McGarry, S. (2025). Determining the success of clinical outcomes for thumbimmobilization compared to no thumb immobilization in adult non-displaced, non-surgically managed scaphoid fractures: A systematic review. Hong Kong journal ofoccupational therapy. The Skinny:This study…
Sign-up to Get Updates Straight to Your Inbox!
Sign up with us and we will send you regular blog posts on everything hand therapy, notices every time we upload new videos and tutorials, along with handout, protocols, and other useful information.